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Virtual data rooms serve as a secure storage facility for documents used during legal proceedings, or IPOs. The VDR is accessible via a specific Internet link that only allows authorized parties to see and edit data. Virtual data rooms are typically used by companies involved in M&A deals because they provide an secure and safe way for the parties to share confidential documents that could be compromised or leaking through email, fax or even regular mail.
The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling is involved in many biological effects that include the metabolic processes of calcium and phosphorous parathormone release, cell expansion and control of adaptive and innate immunity.
A T > C alteration in the promoter region of the VDR variant (rs11568820) removes the binding site of the transcription factor Cdx2 just upstream of exon 1. This results in a smaller protein with reduced transcriptional activity. The F variant is found in high frequency among Asians and Europeans and is not found in a high frequency in Sub-Saharan Africans.
The findings of this study have improved our understanding of the role VDR gene polymorphisms can have in regulating the response to dietary supplementation with calcium calcitriol. Carriers of the TaqI polymorphism and the FF genotype of the FokI polymorphism show higher transcriptional activation of VDR and are associated with improved calcium absorption and bone mineral density and reduced risk of fractures [34, 35]. To improve our understanding of the role that these genetic variants have in vitamin D supplementation, we need to conduct more research with the same design.